Notch-RBP-J signaling regulates the mobilization and function of endothelial progenitor cells by dynamic modulation of CXCR4 expression in mice.

Bone marrow (BM)-derived endothelial progenitor cells (EPC) have therapeutic potentials in Flax Seeds promoting tissue regeneration, but how these cells are modulated in vivo has been elusive.Here, we report that RBP-J, the critical transcription factor mediating Notch signaling, modulates EPC through CXCR4.In a mouse partial hepatectomy (PHx) mode

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